Nesby has released eight solo studio albums, including her 2025 return project, ANNiversary, a collection of original R&B music centered on themes of love, emotional maturity, and empowerment.

Beyond music, Nesby is also known for her acting work in film and television, including appearances in Queen Sugar, Atlanta, The Ms. Pat Show, and the national tour of Tina: The Tina Turner Musical. In 2025, she executive produced and narrated the Oscar-qualifying documentary short CIRILO, A Legacy Untold, which explores the life of civil rights figure Cirilo McSween.